Nf1 patients may have "cafe-au-lait" spots on the skin, neurofibromas of any type, as well as other lesions.  Associated with this may be a variety of other tumors in the brain and the rest of the body.

Nf2 patients may have acoustic neuromas on both sides, or a relative with nf2 and tumors.  These patients may also have a number of other tumors within the central nervous system.